CBD for rats

09 Feb 2020

How To Know If CBD Edibles Are High Quality

Where to Buy Terpenes
(Barata et al., 2019) however greater than these reported in people (∼62 ng/mL) utilizing a plant materials vaporizer with eleven%THC/eleven%CBD hashish (Arkell et al., 2019). The noticed plasma concentrations had been additionally corresponding to plasma CBD observed in rats 4 hours after dermal gel utility, which was the identical time publish-software that CBD decreased alcohol and cocaine seeking (Gonzalez-Cuevas et al., 2018).
CBD Oil typically seems like a mystery product, however it’s actually not hard to grasp it’s advantages. “As with every pharmaceutical, individuals should be very cautious about what they’re giving their pets,” Richter said.
Fortunately, these adjustments are nonetheless usually going to be sufficiently small that it might not trigger a drug-sniffing canine to react. The greatest delivery system is one that gives an optimal dose for a desired duration with few unwanted unwanted side effects. Flower for smoking or vaping is on the market in many medical marijuana dispensaries, however many medical patients choose smoke-free merchandise made from hashish extract. The time of onset and length of impact differ relying on the method of administration.

The addictiveness of synthetic marijuana and the intensity of its effects have caused some folks to match it to crack and meth. Common withdrawal symptoms are just like those associated with marijuana dependancy, including headache, depression, anxiety and irritability.
Cannabidiol (CBD), a cannabinoid compound found in many strains of the Cannabis genus, has skilled current reputation for claimed helpful results on well being and nicely-being (Lewis, 2019). Another in style set of CBD products purport to ship the drug transdermally through oils and lotions, and one more range orally by way of gummy candies and different edible items. The Agriculture Improvement Act of 2018 which was signed into legislation in the USA in December of 2018 expanded authorized hemp cultivation for the manufacturing of cannabidiol (Bourque, 2018). CBD use has been promoted by social and traditional media “lifestyle” celebrities, together with for nervousness associated to impending youngster start (Haller, 2019). Outside the United States, countries across the globe have started permitting cannabidiol (CBD) for use legally inside their borders.
hemp facial cleanser corresponding to Michelle Peace, a forensic scientist at Virginia Commonwealth University who has found artificial marijuana in her personal testing of CBD vapes, said the federal authorities should act quickly to guard the public. Because CBD is the active ingredient in an FDA-permitted drug, the FDA is responsible for regulating its sale within the U.S. But if CBD products are found to contain narcotics, the company considers the investigation a job for the DEA, an FDA spokesman said.

CBD Creams
In the nociception experiment, THC elevated tail-withdrawal latency after inhalation of vapor for half-hour within the mg/mL concentrations however not on the 25 mg/mL focus. CBD didn’t considerably alter nociception by itself or significantly alter the anti-nociceptive effect of THC (50 mg/mL). These findings align with prior analysis examining the parenteral injection of CBD. For instance, CBD is inactive in a tail withdrawal assay in rat when injected by itself or when co-injected with THC, despite enhancing the consequences of THC on paw stress nociception (Britch et al., 2017).

Vapor inhalation of cannabidiol (CBD) in rats


That stated, analysis indicates that artificial marijuana use amongst young folks is declining. According to the 2017 Monitoring the Future survey, almost 4 p.c of high school seniors admitted to smoking Spice prior to now 12 months, down from about 11 % in 2011. These three drugs all have an inconsistent high quality, and individuals who often use them usually develop addictive behaviors.
CBD derived from hemp crops contains little to no THC (less than zero.three% according to federal law within the U.S.), and therefore should not put an individual vulnerable to growing cannabis withdrawal signs that may come from heavier THC consumption. A 2011 examine concluded that CBD has a better security profile compared to THC and other cannabinoids.
Each product has a particular set of benefits–be happy to e-mail us at you would like a suggestion on your pet. When you are giving your dog the right dose on the proper frequency, you will notice an improvement in their situation. Figuring out how usually you need to give your canine CBD oil will take time and endurance, however the payoff is well worth the effort.

CBD products are really easy to consume that some people are worrying about how much is ‘an excessive amount of.’What happens when you accidentally (or intentionally) take an excessive amount of CBD? Let this text serve as a follow-up for our In-Depth Guide to Tincture Dosing article we published just a few months ago. Pure Hemp has failed to determine beyond genuine dispute that a liquefied model of cannabinoids and associated chemical compounds on the concentrations specified within the 911 Patent is anything like a natural phenomenon.
Upon cultivation, we use Supercritical CO2 Full Plant Extraction, which is thought to be the safest and most efficient approach to extract our crops, retaining the complete molecule construction. To filter out the THC, lipids, wax, and other undesirable plant matter, we take away them beneath a state-of-the-art chromatography process.

Evidence means that CBD is also used to assist fight the opposed results of THC, such as cannabis withdrawal signs. In a 2013 report, researchers administered CBD to a 19-yr-outdated lady with cannabis withdrawal syndrome over a ten day period, which successfully resulted in decreased withdrawal signs. Another research, conducted in 2010 and revealed in Neuropsychopharmacology, examined a total of 94 hashish customers to see what function CBD-to-THC ratios played in reinforcing the consequences of medication and implicit attentional bias to drug stimuli. Compared with people who smoke of low-CBD strains, the study found that people who smoke of excessive-CBD strains confirmed lowered attentional bias to drug and meals stimuli, as well as lower self-rated liking of cannabis stimuli. The analysis team concluded that “CBD has potential as a treatment for hashish dependence” and could supply a potential therapy for other addictive issues.
Most CBD is made from hemp, a cannabis selection cultivated for fiber or different makes use of. Unlike its extra well-known cousin THC, cannabidiol does not get customers excessive.
Sales of CBD have been driven in part by unproven claims that it can reduce ache, calm anxiety, improve focus and even prevent illness. Most CBD oil side effects, similar to drowsiness and fatigue, are similar to hemp oil unwanted effects, despite the fact that this hemp fiber-derived product often does not contain any CBD or THC. With its low potential for habit and abuse, CBD’s withdrawal results should be minimal. But every person should weigh the potential threat versus benefits for themselves.
Here is some helpful info that provides peace of mind to any pet house owners thinking about serving to their canine with CBD oil. These recent and growing CBD use tendencies immediate renewed interest in preclinical study of the potential influence of CBD, both to check claims of helpful results on health and nicely-being and to determine any doubtless dangers. Pre-medical experiments sometimes inject rodents with CBD i.p. which may not reflect the pharmacokinetic profile noticed after vapor inhalation.
One of the first things you are able to do to proactively discover the proper CBD product for you is to analysis wherethe CBD comes from; and to try this, you should return to the source – hemp! When it involves Envy’s products, 100% of our hemp is grown within the USA from farms that DO NOT use pesticides.
Recently there was a rise in the emergence of terminally fluorinated synthetic cannabinoids, similar to 5F-PB-22 (fluorinated version of PB-22) and XLR-eleven (fluorinated version of UR-a hundred and forty four). South Korea’s National Forensic Service reported that 90% of all seized artificial cannabinoids in 2013 were fluorinated, compared to no fluorinated synthetic cannabinoids reported in 2010. 5F-derivations (terminal fluorination) of the artificial cannabinoids have been found to be about 2-5 occasions more potent at CB1 receptors than their un-fluorinated counterparts,[four] as shown in Table 2. Many of the early synthetic cannabinoids that have been synthesized to be used in research were named after both the scientist who first synthesized them or the institution or firm the place they originated.
Researchers used an unbiased lab to test eighty four merchandise from 31 firms. According to documents filed in a California court by a former company bookkeeper, a business referred to as Mathco Health Corporation offered Yolo merchandise to a distributor with the same handle as the 7 to eleven Market the place Jenkins stopped. Two different former workers advised AP that Yolo was a Mathco product. One web site advertises artificial marijuana for as little as $25 per pound — the identical amount of natural CBD prices hundreds or even thousands of dollars. “People have began to see the market grow and there are some fly-by-evening corporations trying to make a fast buck,” stated Marielle Weintraub, president of the U.S.
“Unlike CBD, there isn’t any way to convert H2CBD to intoxicating THC,” he said. A artificial, non-intoxicating analogue of cannabidiol (CBD) is efficient in treating seizures in rats, based on analysis by chemists on the University of California, Davis.
-aspartate receptor-mediated molecular events, and changes in cyclic adenosine monophosphate. Identification of particular sites of change in these expanded networks could present therapeutic targets for medication to stop network enlargement. The network expansion mechanisms noticed in AGS kindling might make clear potential basic mechanisms of community expansion, including those seen in persistent pain and affective and nervousness disorders. Thus, a noradrenergic deficit in NE might underlie each the susceptibility to seizures and despair-like behaviors in this mannequin. A critical check of this hypothesis would be to find out whether or not drugs that increase NE signaling may attenuate the depressive-like behaviors in addition to the seizure susceptibility.
These include drowsiness, attainable diarrhea, dry mouth, and different mild signs. But you don’t have to let worry of critically hurting your dog prevent you from giving CBD oil a try. eight,9-Dihydrocannabidiol (H2CBD) is an artificial molecule with an analogous construction to CBD. Mascal’s laboratory developed a simple methodology to inexpensively synthesize H2CBD from commercially available chemical compounds.

Wisely Extra High Potency Hemp CBD Oil instructed doses


Synthetic marijuana products are usually sold in colourful, shiny pouches or plastic bottles emblazoned with catchy names, similar to Matrix, Blue Giant, Scooby Snax and Black Mamba. Then folks started displaying up in emergency rooms, and horror stories about their reactions to artificial marijuana started airing on the nightly information. When Spice and K2 first hit the market in the early to mid-2000s, many individuals assumed the substances have been a protected, pure and legal different to marijuana.
Typically, it’s beneficial that canine dealing obtain a dose each eight hours. The greatest way to nail the best frequency is to strive rising or lowering the dose and see how your dog responds. Deciding how usually you need to give your dog CBD oil is pretty much the same as with the rest you give them.
This might recommend that in some circumstances the route of administration is crucial to the impact of CBD, the place inhalation, transdermal and oral routes are already frequent in human consumer populations. The primary discovering of this study was to substantiate that vapor inhalation using an e-cigarette primarily based system elevates the plasma levels of CBD in male or feminine rats in a dose (concentration in the PG) dependent method. Furthermore, it was proven that the CBD levels obtained in rats after 30 minutes of inhalation of vapor generated from concentrations of 100 to four hundred mg/mL CBD in the PG car fall inside the plasma levels produced 35 minutes after i.p. The peak plasma concentrations were additionally similar to those reported for day previous piglets after 1.0 mg/kg CBD, i.v.
Charlotte’s Web exams the soil they use for heavy metals before they plant, supervising the complete develop process of every seed that goes into that dust. They make their oils using the whole plant and check the ultimate product to make sure that every bottle contains the proper levels of phytocannabinoids. It’s easy to get caught up within the scientific terms if you’re simply attempting to figure out how CBD oil can help you relax after work, with out the hangover you get whenever you suck down a bottle of wine to unwind. But, even though the terms could be advanced, learning about the way in which CBD oils really work in the body is definitely pretty cool.
This could also be because of confusion between non-intoxicating CBD and its intoxicating counterpart, THC. Because of the way in which CBD interacts with receptors in the body’s endocannabinoid system, it doesn’t have the psychoactive effects of THC. In truth, CBD principally blocks THC’s entry to these receptors found throughout the nervous system, thereby reducing a few of THC’s results. Many teens who become addicted to Spice expertise vivid hallucinations and suicidal thoughts.
  • These recent and rising CBD use tendencies prompt renewed interest in preclinical research of the potential impression of CBD, each to test claims of helpful results on health and well-being and to establish any likely risks.
  • When you might be giving your dog the right dose on the proper frequency, you will note an improvement of their condition.
  • CBD inhalation reduces physique temperature in rats, in a fashion that depends partially on the 5-HT1A receptor subtype, but CBD doesn’t seem to take action when administered by parenteral injection.
  • According to the 2017 Monitoring the Future survey, nearly four % of highschool seniors admitted to smoking Spice prior to now yr, down from about 11 percent in 2011.
  • But because it comes from extracts of cannabis or hemp crops, CBD poses authorized issues in some states and beneath federal regulation.

Since THC can be addictive and quite a few CBD products include varying ranges of THC, the query of whether or not CBD oil is addictive can rely upon the place the CBD comes from. A 2013 examine printed within the Journal of Addiction Medicine reported two cases of suspected withdrawal syndrome associated to the long-time period use of synthetic cannabinoids. Although the researchers described an absence of suitable remedy choices for withdrawal signs, they cited therapy with benzodiazepines as an affordable and efficient first-line approach.
They could be made with a wide range of synthetic chemicals engineered to mimic the results of THC, the principle psychoactive ingredient in pot. Spice just isn’t specifically prohibited in Canada, but artificial cannabis mimics are listed as a schedule II drug. Products containing CBD have recently turn into well-liked for their supposed well being effects and because the compound does not trigger a high. CBD can be being investigated as a pharmaceutical compound for circumstances including nervousness, epilepsy, glaucoma and arthritis. But because it comes from extracts of cannabis or hemp plants, CBD poses authorized issues in some states and under federal regulation.
The researchers examined synthetic H2CBD in opposition to herbal CBD in rats with induced seizures. H2CBD and CBD had been found to be equally efficient for the discount of each the frequency and severity of seizures. “It’s a much safer drug than CBD, with no abuse potential and would not require the cultivation of hemp,” said Mark Mascal, professor in the UC Davis Department of Chemistry.
Drug-sniffing dogs are highly effective, extremely educated, tools utilized by police and legislation enforcement. They are frequent but do not sometimes react to hemp-extracted CBD oil merchandise.
Thus, the plasma levels obtained by vapor inhalation are those who produce physiological effects within the rat. Only minor sex differences had been observed, with slightly decrease CBD noticed within the male rats after vapor inhalation or after a mg/kg adjusted i.p.
Also, it’s worth nothing that while CBD oil is typically fairly secure for cats and canine, hashish plants usually are not. “There is loads of documentation of marijuana toxicity in cats, for those that nibble on the vegetation,” Guess says. Phytocannabinoids like CBD (phyto that means “plant”–as in, a compound that occurs naturally in a plant) work with the Endocannabinoid System.
It can also be potential to chemically convert CBD to tetrahydrocannabinol (THC), the intoxicating compound in marijuana. To proactively regulate your dosing, where you buy your CBD merchandise play a big half. The media is fairly on-prime of issues in terms of publicizing unfavorable protection in the direction of a selected occasion or product.
Over a week long period, those treated with CBD decreased the number of cigarettes smoked by forty%, whereas these with the placebo showed no notable difference. It’s potential to avoid THC when utilizing a CBD product but the mixture of CBD and THC is understood to produce an entourage effect, boosting therapeutic benefits whereas subduing unfavorable unwanted effects. For instance, in a 2010 research involving sufferers with cancer pain, researchers found that the mixture of THC and CBD was more effective CBD Growers in treating the ache than the THC and placebo combination. While CBD doesn’t produce the identical addictive results as THC, it’s possible that someone who takes giant quantities of CBD every day may experience unwanted side effects such as changes in sleep, inflammation, and nervousness if they stop suddenly. While Canna-Pet and K2 produce euphoric and stress-free results just like those of marijuana, artificial marijuana is more highly effective and unpredictable than pot.
Basically, when you frequently deplete your self by way of annoying workdays and activity-stuffed weekends, a CBD oil may help. Established in where can i get my cbd oil tested , Green Remedy is a number one provider of high quality hemp derived CBD products. We also wholesale the formulated CBD oil and 99+% CBD isolate that we produce at our facility. Keep in thoughts, levels of terpenes could range within hemp-extracted CBD brands. It is possible that one product of hemp-extracted CBD oil may show adjustments from one bottle to the subsequent.

Epilepsy


Despite growing popularity there’s a deficit of pre-clinical data on the breadth of potential advantages and harms, as recently reviewed (Boggs et al., 2018). Although sometimes termed non-psychoactive as a result of a scarcity of lots of the results related to Δ9-tetrahydrocannabinol, it has been proven more lately to have pharmacological results in humans and in pre-scientific models. CBD has been approved for remedy of two seizure problems within the US (Sekar and Pack, 2019) and has been accredited, in combination with THC, for spasticity related to multiple sclerosis in Canada (Keating, 2017; Oreja-Guevara, 2012). CBD oil is an increasingly in style cannabis product that’s typically marketed for weight loss. Although the dad and mom reported a reduction in epilepsy symptoms, 30% of them claimed that CBD oil significantly elevated their kids’s appetite (27).
It has lately been shown that CBD may cut back methamphetamine looking for (Hay et al, 2018) and alcohol and cocaine seeking (Gonzalez-Cuevas, et al, 2018) in rats. CBD additionally attenuates reminiscence impairment associated with nicotine withdrawal in mice (Saravia et al 2019) however does not alleviate cognitive impairment associated with nicotine abstinence in human people who smoke (Hindocha et al., 2018a).
The outcomes of AP’s lab testing echo what authorities have found, according to a survey of regulation enforcement companies in all 50 states. At least 128 samples out of more than 350 tested by authorities labs in nine states, nearly all within the South, had artificial marijuana in merchandise marketed as CBD. Gummy bears and other edibles accounted for 36 of the hits, while practically all others were vape merchandise.

How many drops are in a dropper full?

Remember: 1 bottle = 30 dropper fulls. 1 dropper full = 35-40 drops*

Guidance on Using CBD


The way artificial marijuana interacts with mind cells would possibly account for why it’s so addictive. Research signifies that some versions of the drug bind to the brain’s cannabinoid receptors 100 instances more tightly than the THC in marijuana does.
Mississippi authorities additionally discovered fentanyl, the highly effective opioid concerned in about 30,000 overdose deaths final year. Some operators are cashing in on the CBD craze by substituting cheap and illegal synthetic marijuana for pure CBD in vapes and edibles corresponding to gummy bears, an Associated Press investigation has discovered. That’s as a result of what he was vaping did not have any CBD, the suddenly popular compound extracted from the cannabis plant that entrepreneurs say can deal with a variety of illnesses without getting users high. Some operators are cashing in on the CBD craze by substituting low cost and illegal synthetic marijuana for pure CBD in vapes and edibles similar to gummy bears.
It is, however, essential to grasp that Spice and marijuana are fully different medicine. People who’re addicted to Spice may also experience drug cravings, sweating, coronary heart palpitations, elevated blood strain, insomnia and nightmares. Synthetic marijuana is addictive, and individuals who often use the drug might experience withdrawal signs when they abruptly stopping utilizing it. People who use Spice or K2 can develop excessive anxiousness and agitation, intense hallucinations and violent behaviors. The drugs may cause an array different bodily effects, starting from nausea and vomiting to bleeding, extreme organ damage and even dying.
The greater concern is discussing this course of therapy with your veterinarian. “Statement from FDA warning about significant well being dangers of contaminated unlawful synthetic cannabinoid merchandise which might be being encountered by FDA” (Press release). In May 2016, the Psychoactive Substances Act[ninety nine] came into pressure, which intends to restrict the production, sale and provide of new psychoactive substances. AP-commissioned testing of two CBD vape cartridges marketed under Maloney’s Hemp Hookahzz brand found no artificial marijuana. The U.S. Food and Drug Administration has permitted one CBD-based mostly drugs for treating seizures associated with two uncommon and extreme types of epilepsy, but says it can’t be added to meals, drinks or dietary dietary supplements.
We DO NOT use artificial gentle to simulate “perfect world” situations. Instead, our farms are all outside, utilizing the Sun and organic practices to cultivate a healthy yield of hemp. Concerning the legality of CBD merchandise, the Federal government permits the manufacturing of commercial hemp, however does not necessarily legalize CBD-specifically. This authorized gray area is emboldened even more so as certain state laws can both allow it in its entirety or ban it altogether. Be positive to take a look at our CBD Legality damaged down state-by-state in a previous article.
In addition to that, shady counterfeiters are making fake CBD oil using synthetic cannabinoids, like those present in Spice and K2. Marijuana-derived CBD is extracted from marijuana crops which are often grown for his or her intoxicating properties. Unlike hemp-extracted CBD, marijuana-derived CBD oil usually incorporates ranges of THC that exceed the federal 0.3% restrict. In the event the CBD oil has particularly high levels of THC, an individual might presumably expertise hashish withdrawal symptoms if the oil was used to extra. CBD oil with THC ranges above zero.three% is simply obtainable in states with medical or adult-use cannabis legalization.

It’s Time to Finally Learn the Difference Between CBD Oil and Hemp Oil


These terpenes are generally known as pinene, caryophyllene, and beta-caryophyllene. THC-free hemp-extracted CBD merchandise don’t have excessive ranges of those terpenes unless they are somehow injected into the product. Hemp-extracted CBD-heavy hemp tinctures have these terpenes current, but the amounts are normally so small that canines likely would not react. Drug-sniffing canines are often seen at airports, public occasions, and site visitors stops.
The choice was rendered on Pure Hemp’s motion for partial summary judgment, and so will not be immediately appealable. Fake or spiked CBD is sufficient of a concern that leaders of the U.S. Hemp Authority business group developed a certification program for CBD pores and skin and well being merchandise.

Can drug dogs smell if you’re high?

In addition to any differences in your behavior when you are intoxicated or high, dogs would be able to pick up on changes in your smell. Even if the smell is not noticeable to another human, a dog’s sense of smell is tens of thousands of times as sensitive to odors as yours.

AP commissioned laboratory testing of the vape oil Jenkins used plus 29 other vape merchandise offered as CBD around the country, with a give attention to brands that authorities or customers flagged as suspect. Ten of the 30 contained kinds of synthetic marijuana — drugs generally often known as K2 or spice that have no recognized medical advantages — while others had no CBD at all.
In Canada, following the passage of The Cannabis Act, which legalized adult-use hashish, each hemp-derived and marijuana-derived CBD are available in all provinces. The European Union (EU) has additionally established regulatory pointers for hemp-derived CBD oil, allowing the cultivation of hemp as long as the THC content material doesn’t exceed 0.2%. A variety of South American nations have additionally loosened restrictions in opposition to CBD oil and medical marijuana in general. Both Mexico and Brazil at present allow CBD products to be imported for sure medical situations, whereas other countries, such as Chile, have already established full-scale medical marijuana packages. Spice and K2 belong to a group of medication known as synthetic cannabinoids.
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Mascal’s laboratory at UC Davis carried out the work in collaboration with researchers on the University of Reading, U.K.
Spice is addictive and may cause unpleasant withdrawal symptoms. “I suppose the larger problem, from a medical perspective, is making sure that animals are dosed appropriately. This means that the CBD oil is having the affect you need it to have, and that you’re not by accident overdosing,” he says. Many CBD products are produced CBD Growers from “hemp extract oil”—and the phrase “extract” in there may be key, as a result of there are also merchandise known as “hemp seed oil.” Despite sounding exactly the identical (complicated), hemp seed oil is definitely a special factor. Doesn’t it feel like you blinked and suddenly CBD oils are in all places?
CBD PERSONAL LUBRICANTS
This is as a result of the levels of terpenes within the hemp-extracted CBD products are often so small that the dog is not fascinated. However, it’s attainable that hemp products could embrace unusually excessive quantities of terpenes and THC at times. For this cause, it’s not really helpful that hemp-extracted CBD oil and hemp products are carried in situations where police canines could be present. Dogs which are educated to smell out medicine are highly specialized. They spend years training to scent very particular terpenes in hashish.
(GEPRs), which embrace GEPR-3s and GEPR-9s, that exhibit differing seizure severities. GEPRs are broadly used to study neuronal networks of generalized seizures and anticonvulsant actions on neurons in this network. DBA mice are utilized in anticonvulsant screening studies and as models of sudden surprising demise in epilepsy (SUDEP). SUDEP preventative studies in DBA mice are investigating medicine that scale back the effect of adenosine or improve the motion of serotonin.
Regardless of how nicely CBD merchandise work for cats, there is additionally the difficulty of legality. If a hashish product incorporates lower than zero.three p.c THC, it’s categorised as “hemp,” which isn’t a restricted substance.
CBD produces at least some of its effects, in vivo, by performing as an agonist at the serotonin 1A (5-HT1A) receptor subtype. For example, intravenous CBD dose-dependently decreases the firing fee CBD Growers of 5-HT neurons in dorsal raphe area in a manner that may be prevented by the 5-HT1A antagonist WAY 100,635 but not the CB1 antagonist AM251 (De Gregorio et al., 2019).
Why Use CBD Tinctures Over Other Products?

How To Know If CBD Edibles Are High Quality(Barata et al., 2019) however greater than these reported in people (∼62 ng/mL) utilizing a plant materials vaporizer with eleven%THC/eleven%CBD hashish (Arkell et al., 2019). The noticed plasma concentrations had been additionally corresponding to plasma CBD observed in rats 4 hours after dermal gel utility, which was […]

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